• About
  • Advertise
  • Privacy & Policy
  • Contact
Tech News, Magazine & Review WordPress Theme 2017
  • Home
  • Gaming

    To regain advertiser trust, Facebook is tracking ads by the millisecond

    National Academy of Sciences endorses embryonic engineering

    Google has been asked to take down over a million websites

    Watch Dogs 2 Update Coming This Week, Here’s What It Does

    The Analogue Nt Mini is the perfect NES console for video game lovers

    GoPro’s Karma drone is back on sale after design flaw made them fall out of the sky

  • Gear
    • All
    • Audio
    • Camera
    • Laptop
    • Smartphone

    Apple Watch Series 2 Is Swimproof and Comes With Built-In GPS

    National Academy of Sciences endorses embryonic engineering

    Jack Dorsey says he’ll continue running both Square and Twitter

    Fujifilm X-T2 review: The definition of a great camera

    The Warby Parker of hair color, Madison Reed, scores new funding and a CMO

    Shopify CEO attempts to defend continued hosting of Breitbart’s online store

    Trending Tags

    • Best iPhone 7 deals
    • Apple Watch 2
    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • iOS 10
    • iPhone 7
    • Sillicon Valley
  • Computers

    To regain advertiser trust, Facebook is tracking ads by the millisecond

    Google has been asked to take down over a million websites

    Watch Dogs 2 Update Coming This Week, Here’s What It Does

    Fujifilm X-T2 review: The definition of a great camera

    Shopify CEO attempts to defend continued hosting of Breitbart’s online store

    SpaceX targets February 18 for Dragon resupply mission to ISS

  • Applications

    Apple Watch Series 2 Is Swimproof and Comes With Built-In GPS

    To regain advertiser trust, Facebook is tracking ads by the millisecond

    National Academy of Sciences endorses embryonic engineering

    Google has been asked to take down over a million websites

    Watch Dogs 2 Update Coming This Week, Here’s What It Does

    Jack Dorsey says he’ll continue running both Square and Twitter

  • Security

    To regain advertiser trust, Facebook is tracking ads by the millisecond

    National Academy of Sciences endorses embryonic engineering

    Google has been asked to take down over a million websites

    Watch Dogs 2 Update Coming This Week, Here’s What It Does

    The Warby Parker of hair color, Madison Reed, scores new funding and a CMO

    Shopify CEO attempts to defend continued hosting of Breitbart’s online store

No Result
View All Result
  • Home
  • Gaming

    To regain advertiser trust, Facebook is tracking ads by the millisecond

    National Academy of Sciences endorses embryonic engineering

    Google has been asked to take down over a million websites

    Watch Dogs 2 Update Coming This Week, Here’s What It Does

    The Analogue Nt Mini is the perfect NES console for video game lovers

    GoPro’s Karma drone is back on sale after design flaw made them fall out of the sky

  • Gear
    • All
    • Audio
    • Camera
    • Laptop
    • Smartphone

    Apple Watch Series 2 Is Swimproof and Comes With Built-In GPS

    National Academy of Sciences endorses embryonic engineering

    Jack Dorsey says he’ll continue running both Square and Twitter

    Fujifilm X-T2 review: The definition of a great camera

    The Warby Parker of hair color, Madison Reed, scores new funding and a CMO

    Shopify CEO attempts to defend continued hosting of Breitbart’s online store

    Trending Tags

    • Best iPhone 7 deals
    • Apple Watch 2
    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • iOS 10
    • iPhone 7
    • Sillicon Valley
  • Computers

    To regain advertiser trust, Facebook is tracking ads by the millisecond

    Google has been asked to take down over a million websites

    Watch Dogs 2 Update Coming This Week, Here’s What It Does

    Fujifilm X-T2 review: The definition of a great camera

    Shopify CEO attempts to defend continued hosting of Breitbart’s online store

    SpaceX targets February 18 for Dragon resupply mission to ISS

  • Applications

    Apple Watch Series 2 Is Swimproof and Comes With Built-In GPS

    To regain advertiser trust, Facebook is tracking ads by the millisecond

    National Academy of Sciences endorses embryonic engineering

    Google has been asked to take down over a million websites

    Watch Dogs 2 Update Coming This Week, Here’s What It Does

    Jack Dorsey says he’ll continue running both Square and Twitter

  • Security

    To regain advertiser trust, Facebook is tracking ads by the millisecond

    National Academy of Sciences endorses embryonic engineering

    Google has been asked to take down over a million websites

    Watch Dogs 2 Update Coming This Week, Here’s What It Does

    The Warby Parker of hair color, Madison Reed, scores new funding and a CMO

    Shopify CEO attempts to defend continued hosting of Breitbart’s online store

No Result
View All Result
Desknery News
No Result
View All Result

Supercomputer’s Findings Suggest Why Patients Worsen, Get Range Of Symptoms

developer1 by developer1
September 14, 2020
Home Technology
Share on FacebookShare on Twitter
0 0
Read Time:3 Minute, 16 Second

The bizarre cascade of effects of the coronavirus may be due to the excessive production of a chemical that regulates blood pressure — throwing the body’s respiratory, gastrointestinal, and neurological pathways off-balance, a new study has found.

Researchers at the Oak Ridge National Laboratory in Tennessee, using its supercomputers — one of which is the second-fastest in the world — analyzed lung fluid samples from nine coronavirus patients with severe cases in Wuhan, China, Business Insider reported.

The computers detected big differences in way the patients expressed certain genes relative to the way healthy people do. Based on those abnormalities, the researchers came up with a new theory: Patients with severe COVID-19 may experience what’s known as a “bradykinin storm.”

The blood pressure regulating chemical produced extreme excess and throws off major body systems, they found — a theory that aligns with researchers’ growing view of the coronavirus as a vascular disease instead of a respiratory one, BI reported.

We were really scratching our heads for a while, how does this disease have this darn broad set of symptoms across lots of different organ systems?” Dr. Daniel Jacobson, the lead researcher behind the supercomputer study, told BI.

‘”As we looked at the effects of bradykinin, our model was that this virus can affect several different types of tissues, several different organs.”

Scientists already know that the coronavirus binds to cell receptors called ACE2. That’s how the virus sneaks into the body’s upper respiratory tract, then infects organs like the lungs, heart, kidneys, or intestines.

But the supercomputers found coronavirus patients had a 200-fold increase in the expression of ACE2 relative to a healthy person, and an eight-fold decrease in the expression of ACE, a protein that normally works with ACE2 to keep blood pressure in check.

“This system that is normally very carefully balanced — COVID-19 really throws it out of whack,” Jacobson told the news outlet.

The researchers believes the imbalance leads to the over-production of bradykinin, which swoops in to keep blood pressure from getting too high. In severe cases, the cycle seems to go into overdrive: The body can’t stop producing bradykinin. This is what researchers call a “bradykinin storm.” BI reported.

“Everywhere we go in the body and look at the symptoms being reported, they map pretty well to exactly what you’d expect to see from bradykinin,” Jacobson told BI.

In May, Michigan researchers also hypothesized that a bradykinin response could lead to life-threatening respiratory complications in some COVID‐19 patients, finding the bradykinin response was to blame for leaky blood vessels observed in those patients’ lungs, BI reported.

The researchers behind that work suggested that a drug called icatibant, which blocks the body’s signal to produce bradykinin, could help treat infected patients. A small follow-up study showed that four of nine patients who got the drug no longer needed oxygen support after 10 to 35 hours. 

But Jacobson’s study found evidence vitamin D might hinder a bradykinin storm from developing in the first place. His study also supports the idea that corticosteroids can improve survival rates for COVID-19 patients. 

“To be honest, I’m worried that this proposal is almost too neat and form-fitting,” Derek Lowe, a medicinal chemist, wrote in Science Magazine. “Rarely do you get something that falls together this well.”

Still, he added, the findings are “pretty plausible.”

According to BI, Jacobson’s team thinks once that bradykinin storm takes off, it could continue until the body figures out how to reset it. It’s  unclear whether any available treatments would make a difference for long-haul patients.

“That’s part of the joy of science,” Jacobson told BI. “For every answer you have, it raises 10 more questions.”Related Stories:

  • Cat Drugs May Fight Coronavirus, Says New Study
  • FDA Suspends COVID-19 Emergency Approval Treatment

© 2020 Newsmax. All rights reserved.

Share

Facebook
Twitter
Pinterest
LinkedIn

About Post Author

developer1

abdullah@evertise.net
Happy
Happy
0 0 %
Sad
Sad
0 0 %
Excited
Excited
0 0 %
Sleepy
Sleepy
0 0 %
Angry
Angry
0 0 %
Surprise
Surprise
0 0 %
developer1

developer1

Next Post

Pfizer CEO: Vax Distribution Should Be Private-Govt Collaboration

Recommended.

“THE LAUNCH” THRILLINGLY EUPHORIC INSOMNIAC RADIO SHOW BY DEVOLVE

March 20, 2021

Enuit Discusses Remote Implementations with ComTech Advisory

March 31, 2021

Trending.

Five biggest hacks in the history of the Cyber Security

Five biggest hacks in the history of the Cyber Security

January 26, 2023
Heal Yourself with the Help of Daniel the Healer

Heal Yourself with the Help of Daniel the Healer

January 4, 2023
Desknery News

© 2022 Desknery - All rights reserved.

Quick Links

  • About
  • Advertise
  • Privacy & Policy
  • Contact

Follow Us

No Result
View All Result
  • Home
  • Gaming
  • Gear
  • Computers
  • Applications
  • Security

© 2022 Desknery - All rights reserved.